Repellency of Veratraldehyde (3,4-Dimethoxy Benzaldehyde) against Mosquito Females and Tick Nymphs

Arthropod-borne infectious diseases cause many deaths and a major economic burden worldwide. Repellents play an important role in protecting people from biting arthropods. The repellency of veratraldehyde, known food additive, the WJ-1041 formulation containing 10% veratraldehyde was tested against Aedes albopictus Culex pipiens pallens females Haemaphysalis longicornis nymphs using arm-in-cage, indoor or filter paper tests. Veratraldehyde exhibited similar to lower than that n,n-diethyl-meta-toluamide (DEET) A. albopictus, but H. longicornis, activity better DEET. solution comparable 20% DEET two mosquitoes. When comparing between (10% veratraldehyde) C. pallens, Albopictus showed complete protection time (CPT) values. However, there small difference depending on insects. absorption via skin minimal, if at all. pharmacokinetic parameters (Cmax Tmax) blood samples rats were not different those control group. Based these results, has high potential be commercialized as repellent agent disease-borne pests near future.